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Abstract #3364

Impaired Biophysical Integrity of Default Mode Network in Type 2 Diabetes Revealed by Magnetization Transfer Imaging

Shaolin Yang 1,2 , Minjie Wu 1 , Olusola Ajilore 1 , and Anand Kumar 1

1 Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States, 2 Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States

Reduced functional connectivity within the brains default mode network (DMN) and impaired connecting white matter tracts have been reported in type 2 diabetes mellitus (T2DM). However, it is unknown whether the DMN nodal regions themselves are also compromised. In this study, magnetization transfer (MT) imaging was applied on twenty T2DM patients and twenty-six healthy controls. Compared with controls, T2DM patients had significantly lower MT ratio (MTR) in posterior cingulate cortex (PCC), while no significant differences in other DMN regions. Reduced PCC MTR correlated with T2DM-related clinical measures. The impaired PCC in DMN may provide insights into neurological pathophysiology of T2DM.

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