Abstract #3370
Characterization of the optic nerve in-vivo using high-resolution APT-CEST
Alex K. Smith 1,2 , Lindsey M. Dethrage 2,3 , Samantha By 1,2 , Siddharama Pawate 4 , and Seth A. Smith 2,3
1
Biomedical Engineering, Vanderbilt
University, Nashville, TN, United States,
2
Vanderbilt
University Institute of Imaging Science, Vanderbilt
University, Nashville, TN, United States,
3
Radiology
and Radiological Sciences, Vanderbilt University,
Nashville, TN, United States,
4
Neurology
and Neuroimmunology, Vanderbilt University, Nashville,
TN, United States
Visual dysfunction is a hallmark of MS and may arise
from damage to components of the visual system, such as
the optic nerve (ON). Understanding the changes that
accompany this damage may offer a biomarker for MS. We
implemented an APT-CEST protocol to characterize amide
content in healthy ON tissue. Nine controls were imaged
at 3T and the data fit to a model of the
direct-water-saturation curve. The mean %AUC values in
each ON were found to be 1.741%(L) and 1.631%(R).
These findings suggest CEST can be accurately quantified
in healthy ON and may provide a biomarker for MS
prognosis.
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