Abstract #3369
Oxidative Stress Sensitive Magnetization Transfer
Rong-Wen Tain 1,2 , Weiguo Li 3 , Tibor Valyi-Nagy 4 , Xiaohong Joe Zhou 1,2 , and Kejia Cai 1,2
1
Radiology, College of Medicine, University
of Illinois at Chicago, Chicago, Illinois, United
States,
2
Center
for MR Research, College of Medicine, University of
Illinois at Chicago, Chicago, Illinois, United States,
3
Research
Resource Center, University of Illinois at Chicago,
Illinois, United States,
4
Pathology,
College of Medicine, University of Illinois at Chicago,
Illinois, United States
Magnetization transfer (MT) can occur via chemical
exchange saturation transfer (CEST) and/or dipole-dipole
interactions (Nuclear Overhauser Enhancement or NOE).
This study aims to investigate the sensitivity of MT in
the broad definition to oxidative stress through
controlled ex vivo studies. Z-spectra were acquired from
egg white and lamb brain tissues treated with hydrogen
peroxide for one hour. In the Z-spectra, distinctive
reductions in the NOE, CEST and the semi-solid MT
contrasts were seen due to induced oxidative stress. We
demonstrated the sensitivity of magnetization transfer
is dependent on the level of induced oxidative stress.
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