Meeting Banner
Abstract #3368

Sufficiency of Two-Pool Model for Quantitative Magnetization Transfer Imaging in Tumors

Ke Li 1,2 , Hua Li 1,3 , Xiao-Yong Zhang 1,2 , Ashley M Stokes 1,2 , Hakmook Kang 4 , Zhongliang Zu 1,2 , Chad C Quarles 1,2 , Daniel F Gochberg 1,2 , John C Gore 1,2 , and Junzhong Xu 1,2

1 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 2 Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 3 Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, 4 Department of Biostatistics, Vanderbilt University, Nashville, TN, United States

Quantitative Magnetization Transfer provides measurements of macromolecular content in biological tissues based on a two-pool model. This might be oversimplified for biological tissues, such as tumor, which consists of multiple water compartments. This work demonstrated that with the presence of intermediate to fast water exchange, the two-pool model is sufficient to describe qMT data in tumors. Numerical simulations validated this hypothesis. Further validations were performed by injecting Gd-DTPA to selectively alter extracellular relaxation properties in tumor bearing animals. Across all dynamics, there were no significant changes in the obtained pool size ratios.

This abstract and the presentation materials are available to members only; a login is required.

Join Here