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Abstract #3367

On the distribution of pure Amide Proton Transfer and pure Nuclear Overhauser Enhancement signals in gray and white matter in the human brain at 7T

Vitaliy Khlebnikov 1 , Jeroen Siero 1 , Jannie Wijnen 1 , Fredy Visser 2 , Peter Luijten 1 , Dennis Klomp 1 , and Hans Hoogduin 1

1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2 Philips Healthcare, Best, Netherlands

Chemical Exchange Saturation Transfer (CEST) has attracted a lot of attention due to its sensitivity to cellular protein content and pH. However, those useful properties, mainly APT (Amide Proton Transfer) and NOE (nuclear overhauser enhancement) are often contaminated with a magnitude of confounding effects, which in turn can lead to error-prone conclusions. The aim of this work is to compare pure effects of APT and NOE in white and gray matter in healthy human brain at 7T.

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