On the distribution of pure Amide Proton Transfer and pure Nuclear Overhauser Enhancement signals in gray and white matter in the human brain at 7T
Vitaliy Khlebnikov 1 , Jeroen Siero 1 , Jannie Wijnen 1 , Fredy Visser 2 , Peter Luijten 1 , Dennis Klomp 1 , and Hans Hoogduin 1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
Healthcare, Best, Netherlands
Chemical Exchange Saturation Transfer (CEST) has
attracted a lot of attention due to its sensitivity to
cellular protein content and pH. However, those useful
properties, mainly APT (Amide Proton Transfer) and NOE
(nuclear overhauser enhancement) are often contaminated
with a magnitude of confounding effects, which in turn
can lead to error-prone conclusions. The aim of this
work is to compare pure effects of APT and NOE in white
and gray matter in healthy human brain at 7T.
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