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Abstract #3366

Whole-brain Amide Proton Transfer (APT) and Nuclear Overhauser enhancement (NOE) imaging in Glioma Patients using low-power steady state pulsed CEST at 7T

Hye-Young Heo 1 , Shruti Agarwal 2 , Craig Jones 1,3 , Jun Hua 1,3 , Nirbhay Yadav 1,3 , Jinyuan Zhou 1,3 , Peter C.M van Zijl 1,3 , and Jay J. Pillai 2

1 Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States, 2 Division of Neuroradiology, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, United States, 3 F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

APT-weighted MRI has shown the potential to detect gliomas, to differentiate glioma cores from peritumoral edema, and to separate recurrent tumor from treatment necrosis. When acquiring Z-spectra using low RF power pulsed steady-state CEST acquisition with the purpose of reducing semi-solid MT contrast (MTC) and reducing and narrowing direct saturation effects, saturation-transfer effects based on slow exchange are pronounced, such as upfield relayed NOE signals and downfield CEST/APT signals. In this study, we assessed the ability of APT/NOE imaging to differentiate histologic grades of de novo primary gliomas at 7T.

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