Abstract #3366
Whole-brain Amide Proton Transfer (APT) and Nuclear Overhauser enhancement (NOE) imaging in Glioma Patients using low-power steady state pulsed CEST at 7T
Hye-Young Heo 1 , Shruti Agarwal 2 , Craig Jones 1,3 , Jun Hua 1,3 , Nirbhay Yadav 1,3 , Jinyuan Zhou 1,3 , Peter C.M van Zijl 1,3 , and Jay J. Pillai 2
1
Division of MR Research, Russell H Morgan
Department of Radiology and Radiological Science, Johns
Hopkins University, Baltimore, Maryland, United States,
2
Division
of Neuroradiology, Russell H Morgan Department of
Radiology and Radiological Science, Johns Hopkins
University, Baltimore, Maryland, United States,
3
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
APT-weighted MRI has shown the potential to detect
gliomas, to differentiate glioma cores from peritumoral
edema, and to separate recurrent tumor from treatment
necrosis. When acquiring Z-spectra using low RF power
pulsed steady-state CEST acquisition with the purpose of
reducing semi-solid MT contrast (MTC) and reducing and
narrowing direct saturation effects, saturation-transfer
effects based on slow exchange are pronounced, such as
upfield relayed NOE signals and downfield CEST/APT
signals. In this study, we assessed the ability of
APT/NOE imaging to differentiate histologic grades of
de
novo
primary
gliomas at 7T.
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