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Abstract #3373

Longitudinal CEST Imaging of Spinal Cord Injury in Monkeys: Fingerprints of Cyst

Feng Wang 1,2 , Zhongliang Zu 1,2 , Tung-Lin Wu 2 , John C. Gore 1,2 , and Li Min Chen 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, 2 Institute of Imaging Sciences, Vanderbilt University, Nashville, TN, United States

Non-human primates provide valuable pre-clinical models for studying spinal cord injuries (SCI). The metabolites and byproducts from injuries could exhibit CEST (Chemical Exchange Saturation Transfer) effects due to their exchangeable protons on hydroxyl, amine and amide residues. Here we recorded and interpreted the z-spectra of abnormalities formed after SCI at 9.4T. Different CEST mapping schemes were compared to evaluate regional changes around the sites of lesions. Characteristic features extracted from z-spectra enable the non-invasive spatial and longitudinal assessments of spontaneous recovery from SCI.

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