Abstract #3374
Age-dependent gagCEST effect in human lumbar intervertebral discs
Frithjof Wickrath 1 , Anja Mller-Lutz 1 , Christoph Schleich 1 , Benjamin Schmitt 2 , Tom Cronenberg 1 , Rotem Shlomo Lanzman 1 , Falk Miese 1 , and Hans-Jrg Wittsack 1
1
Department of Diagnostic and Interventional
Radiology, University Dusseldorf, Medical Faculty,
D-40225 Dusseldorf, NRW, Germany,
2
Healthcare
Sector, Siemens Ltd. Australia, Australia
The aim of this study was to evaluate, if the chemical
exchange saturation transfer effect of
glycosaminoglycans (gagCEST) representing the amount of
glycosaminoglycans alters with age in the cartilage of
human lumbar intervertebral discs. Therefore gagCEST
imaging was applied on a 3T MR scanner. The gagCEST
effect measured using the asymmetric magnetization
transfer ratio decreases with age. These results
strengthen the idea of a loss of glycosaminoglycan
content with age. Hence, age-matched gagCEST analysis is
necessary in future.
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