Meeting Banner
Abstract #3374

Age-dependent gagCEST effect in human lumbar intervertebral discs

Frithjof Wickrath 1 , Anja Mller-Lutz 1 , Christoph Schleich 1 , Benjamin Schmitt 2 , Tom Cronenberg 1 , Rotem Shlomo Lanzman 1 , Falk Miese 1 , and Hans-Jrg Wittsack 1

1 Department of Diagnostic and Interventional Radiology, University Dusseldorf, Medical Faculty, D-40225 Dusseldorf, NRW, Germany, 2 Healthcare Sector, Siemens Ltd. Australia, Australia

The aim of this study was to evaluate, if the chemical exchange saturation transfer effect of glycosaminoglycans (gagCEST) representing the amount of glycosaminoglycans alters with age in the cartilage of human lumbar intervertebral discs. Therefore gagCEST imaging was applied on a 3T MR scanner. The gagCEST effect measured using the asymmetric magnetization transfer ratio decreases with age. These results strengthen the idea of a loss of glycosaminoglycan content with age. Hence, age-matched gagCEST analysis is necessary in future.

This abstract and the presentation materials are available to members only; a login is required.

Join Here