Abstract #3375
Endogenous Urea CEST (urCEST) for MRI monitoring of kidney function
Elena Vinogradov 1,2 , Zheng Liu 3 , Ananth Madhuranthakam 1,2 , Asghar Hajibeigi 1 , Adrien Jump 4 , Ivan Pedrosa 1,2 , Orson W Moe 4 , and Robert E Lenkinski 1,2
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, Texas, United States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Dallas, Texas, United
States,
3
Advanced
Imaging Research Center,Oregon National Primate Research
Center, Oregon Health & Science University, Portland,
Oregon, United States,
4
Internal
Medicine, University of Texas Southwestern Medical
Center, Dallas, Texas, United States
Kidney ailments affect millions of people. Many of these
diseases alter normal pH and urea distribution in
tissue, prior to apparent morphological changes in the
kidney or biochemical changes in blood and urine.
Imaging is a powerful tool to assess regional
alternations. Here we investigate the application of
CEST to monitor kidney function using endogenous urea
(urCEST). We present images from healthy volunteers
acquired at 3T as well as urCEST modulation following a
simple intervention. UrCEST may become a powerful asset
in the non-invasive evaluation of kidney function and
disease. Moreover, application of quantification methods
may lead to pH and urea concentration maps in-vivo.
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