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Abstract #3376

Chemical exchange saturation transfer (CEST) MR imaging of rat liver with fasting or CCl4 intoxication

Shuzhong Chen 1 , Min Deng 1 , Jing Yuan 2 , and Yi-Xiang Wang 1

1 Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, 2 Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong

CEST MR is a promising molecular imaging technique which enables indirect detection of metabolites with exchangeable protons or molecules. Both APT and glycoCEST value decrease after CCl4 48 hours injection and 24 hours fasting. However, compared with APT, glycoCEST shows high intra- and inter-subject standard deviation in both experiments. This may due to the rapid exchange rate of glycogen hydroxyl protons and their proximity to the water resonance. The observed change in APT reflected the alteration of amide proton levels by injecting CCl4 and fasting. The reliability of glycoCEST in vivo liver at 3T should be further investigated.

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