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Abstract #3377

Can brain tumor microenvironment and associated structures be probed by Amide Proton Transfer at 7T?

Vitaliy Khlebnikov 1 , Daniel Polders 2 , Dennis Klomp 1 , Jeroen Hendrikse 1 , Piere Robe 3 , Eduard Voormolen 3 , Peter Luijten 1 , and Hans Hoogduin 1

1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2 Philips Healthcare, Best, Netherlands, 3 Brain Division, University Medical Center Utrecht, Utrecht, Netherlands

Any difference in micro-environment between normal tissue and tumour can potentially be exploited in therapy. Amide Proton Transfer (APT) imaging is a potentially powerful tool in bringing to light these differences due to its sensitivity to pH and protein content at high spatial resolution. Also, it is important to compare pure effects (without contamination from confounding effects, e.g. water T1 effect) to cast light on pathology. The purpose of this pilot study was to compare true APT with traditional asymmetry (MTRasym) in a variance of brain tumour patients at 7T to investigate the value of APT imaging in tumours.

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