Can brain tumor microenvironment and associated structures be probed by Amide Proton Transfer at 7T?
Vitaliy Khlebnikov 1 , Daniel Polders 2 , Dennis Klomp 1 , Jeroen Hendrikse 1 , Piere Robe 3 , Eduard Voormolen 3 , Peter Luijten 1 , and Hans Hoogduin 1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
Healthcare, Best, Netherlands,
Division, University Medical Center Utrecht, Utrecht,
Any difference in micro-environment between normal
tissue and tumour can potentially be exploited in
therapy. Amide Proton Transfer (APT) imaging is a
potentially powerful tool in bringing to light these
differences due to its sensitivity to pH and protein
content at high spatial resolution. Also, it is
important to compare pure effects (without contamination
from confounding effects, e.g. water T1 effect) to cast
light on pathology. The purpose of this pilot study was
to compare true APT with traditional asymmetry (MTRasym)
in a variance of brain tumour patients at 7T to
investigate the value of APT imaging in tumours.
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