Abstract #3378
Z-spectral modeling for CEST-MRI of bladder cancer
Ryan Nicholas Schurr 1 , Huyen T. Nguyen 2 , Kamal Pohar 3 , Amir Mortazavi 4 , Zarine Shah 2 , Debra Zynger 5 , Michael V. Knopp 2 , and Guang Jia 1
1
Department of Physics and Astronomy,
Louisiana State University, Baton Rouge, Louisiana,
United States,
2
Department
of Radiology, The Ohio State University, Ohio, United
States,
3
Department
of Urology, The Ohio State University, Ohio, United
States,
4
Department
of Internal Medicine, The Ohio State University, Ohio,
United States,
5
Department
of Pathology, The Ohio State University, Ohio, United
States
Z-spectra from healthy and malignant regions of bladder
cancer patients of bladder cancer patients are fit as
separate components upfield and downfield from water,
and the magnitude of the MTR asymmetry is calculated at
2.0 ppm and 3.5 ppm offset frequencies using the results
of the fitting process. The MTR asymmetry at the 3.5 ppm
offset frequency is statistically significantly
different between tumor and normal bladder wall,
suggesting that this technique is able to distinguish
between the two regions.
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