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Abstract #3379

Modulation and regulation of intracellular pH in healthy human brain studied by means of Chemical Exchange Saturation Transfer (CEST) at 7T

Vitaliy Khlebnikov 1 , Alex Bhogal 1 , Jeroen Siero 1 , Michel Italiaander 2 , Vincent Boer 1 , Peter Luijten 1 , Hans Hoogduin 1 , and Dennis Klomp 1

1 Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2 MR Coils BV, Drunen, Netherlands

pH homeostasis is vital to normal cellular physiology. 31P Magnetic Resonance Spectroscopy (31P MRS) is currently a gold standard for the non-invasive measurements of intracellular pH (pHi) using inorganic phosphate (Pi) as a probe. Low resolution and low pH sensitivity are major limitation of 31P-based pH measurements. The aim of this work is to show that emerging APT (Amide Proton Transfer) imaging is superior to 31P MRS in terms of both resolution and pH sensitivity by getting an estimate on buffering capacity of different brain compartments in healthy human brain at 7T.

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