Abstract #3379
Modulation and regulation of intracellular pH in healthy human brain studied by means of Chemical Exchange Saturation Transfer (CEST) at 7T
Vitaliy Khlebnikov 1 , Alex Bhogal 1 , Jeroen Siero 1 , Michel Italiaander 2 , Vincent Boer 1 , Peter Luijten 1 , Hans Hoogduin 1 , and Dennis Klomp 1
1
Department of Radiology, University Medical
Center Utrecht, Utrecht, Netherlands,
2
MR
Coils BV, Drunen, Netherlands
pH homeostasis is vital to normal cellular physiology.
31P Magnetic Resonance Spectroscopy (31P MRS) is
currently a gold standard for the non-invasive
measurements of intracellular pH (pHi) using inorganic
phosphate (Pi) as a probe. Low resolution and low pH
sensitivity are major limitation of 31P-based pH
measurements. The aim of this work is to show that
emerging APT (Amide Proton Transfer) imaging is superior
to 31P MRS in terms of both resolution and pH
sensitivity by getting an estimate on buffering capacity
of different brain compartments in healthy human brain
at 7T.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
