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Abstract #3398

Optimization of Magnetization-Prepared Rapid Gradient-Echo (MP-RAGE) Sequence for Neonatal Brain MRI

Lili He 1 , Jinghua Wang 2 , Mark Smith 3 , and Nehal A. Parikh 1,4

1 Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States, 2 Center for Cognitive and Behavioral Brain Imaging, The Ohio State University, Columbus, Ohio, United States, 3 Radiology Department, Nationwide Children's Hospital, Columbus, Ohio, United States, 4 Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, United States

Three-dimensional T1-weighted sequences such as MP-RAGE are extremely valuable to evaluate neonatal and infant brain injury/development. Yet, the lack of complete myelination and smaller head size results in comparatively lower quality images as compared to adult brains. In this study, we consider WM-GM contrast efficiency as an objective function to optimize neonatal MP-RAGE parameters under optimal k-space sampling by means of computer simulation. Quantitative analysis indicated that WM-GM contrast to noise efficiency of images acquired with our optimal parameters was 20% higher than those using parameters recommended by a published protocol; similarly, mean SNR efficiency was increased by approximately 150%.

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