Abstract #3397
Limitations of T2-contrast 3D-Fast Spin Echo Sequences in the Differentiation of Radiation Fibrosis versus Tumor Recurrence
Andrea Vargas 1 , Laurent Milot 2 , Simon Graham 1 , and Philip Beatty 1
1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
2
Sunnybrook
Research Institute, Toronto, Canada
The use of variable flip angles for 3D fast spin echo
sequences (3DFSE) have shown to alter contrast in
T2-weighted images relative to conventional 2DFSE. While
these alterations of contrast may be minimal in brain
tissues, they can have a great consequences in body
applications that encompass a wide range of T2 values.
In this study we evaluate the performance of current
methods that aim to correct T2-contrast in a cervix
cancer application which has a wide range of T2 values
(35 ms < T2 < 84 ms). We show that the differentiation
between recurrent tumor and radiation fibrosis may be
ambiguous at clinical echo times using 3DFSE.
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