Limitations of T2-contrast 3D-Fast Spin Echo Sequences in the Differentiation of Radiation Fibrosis versus Tumor Recurrence

The use of variable flip angles for 3D fast spin echo sequences (3DFSE) have shown to alter contrast in T2-weighted images relative to conventional 2DFSE. While these alterations of contrast may be minimal in brain tissues, they can have a great consequences in body applications that encompass a wide range of T2 values. In this study we evaluate the performance of current methods that aim to correct T2-contrast in a cervix cancer application which has a wide range of T2 values (35 ms < T2 < 84 ms). We show that the differentiation between recurrent tumor and radiation fibrosis may be ambiguous at clinical echo times using 3DFSE.

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