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Abstract #3397

Limitations of T2-contrast 3D-Fast Spin Echo Sequences in the Differentiation of Radiation Fibrosis versus Tumor Recurrence

Andrea Vargas 1 , Laurent Milot 2 , Simon Graham 1 , and Philip Beatty 1

1 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Sunnybrook Research Institute, Toronto, Canada

The use of variable flip angles for 3D fast spin echo sequences (3DFSE) have shown to alter contrast in T2-weighted images relative to conventional 2DFSE. While these alterations of contrast may be minimal in brain tissues, they can have a great consequences in body applications that encompass a wide range of T2 values. In this study we evaluate the performance of current methods that aim to correct T2-contrast in a cervix cancer application which has a wide range of T2 values (35 ms < T2 < 84 ms). We show that the differentiation between recurrent tumor and radiation fibrosis may be ambiguous at clinical echo times using 3DFSE.

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