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Abstract #3432

Piecewise diffusion tensor estimation for fetal imaging application

Uday Krishnamurthy 1,2 , Ramtilak Gattu 1 , Pavan Kumar Jella 1 , Jaladhar Neelavalli 1,2 , and Ewart Mark Haacke 1,2

1 Department of Radiology, Wayne State University, Detroit, Michigan, United States, 2 Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, United States

Diffusion tensor imaging (DTI) enables us to understand brain maturation and the development of myelin both in neonatal and pediatric populations. However, the same has not been extensively used for in-utero applications, largely owing to fetal motion. In this study we analyzed the feasibility of piece wise approach of acquiring the volume of interest i.e. multiple smaller volumes to encompass the whole volume, using a short TR single shot EPI. This approach enables a DTI volume set (12-directions) to be acquired within 10 secs, which greatly reduces the possibility of data corruption due to fetal motion.

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