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Abstract #3433

Sphingosin-1-Phosphate-receptor modulation ameliorates neonatal white matter damage and improves long-term cognitive development

Yohan van de Looij 1,2 , Meray Serdar 3 , Petra S Hppi 1 , Ursula Felderhoff-Mser 3 , Ivo Bendix 3 , and Stphane V Sizonenko 1

1 Division of Child Growth and Development, University of Geneva, Geneva, Switzerland, 2 Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland, 3 Department of Pediatrics, University Hospital Essen, Essen, Germany

Cerebral white matter injury is a leading cause of adverse neuro-developmental outcome in prematurely born infants. Experimental and clinical data from the adult demyelinating disease multiple sclerosis revealed immunomodulatory and cytoprotective effects of the sphingosine-1-phosphate receptor modulating substance Fingolimod (also known as FTY720). Therefore, the neuroprotective role of FTY720 in a neonatal model of oxygen-toxicity was investigated by using high-field Diffusion Tensor Imaging (DTI), histology and protein analysis. Results provide strong evidence for a protective effect of FTY720 on oligodendrocyte in hyperoxia-induced white matter damage coinciding with microstructural ameliorations detected by DTI in later life.

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