Abstract #3434
Abnormal whiter matter connectivity network organization in children with autism spectrum disorder using diffusion tensor imaging
Shijun Li 1 , Yi Wang 2 , Long Qian 3 , and Lin Ma 4
1
Department of Medical Instruments, PLA
General Hospital, Beijing, Beijing, China,
2
Department
of Stomatology, PLA General Hospital, Beijing, China,
3
Department
of Biomedical Engineering, Peking University, Beijing,
China,
4
Department
of Radiology, PLA General Hospital, Beijing, China
The current study for the first time demonstrated the
disrupted topological organization in c-ASD specific to
school age children using DTI. MRI scanning was
performed on 21 children with c-ASD and 21 age and
gender matched healthy controls. Compared with HC,
decreased characteristic path length (Lp), increased
global efficiency and clustering coefficient were
observed in c-ASD group, while no group effects were
found in other global topological patterns. Our results
suggested that both the global and regional topological
patterns were disrupted in c-ASD, which might provide
key neuroimaging biomarkers to classify the patients
with c-ASD.
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