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Abstract #3434

Abnormal whiter matter connectivity network organization in children with autism spectrum disorder using diffusion tensor imaging

Shijun Li 1 , Yi Wang 2 , Long Qian 3 , and Lin Ma 4

1 Department of Medical Instruments, PLA General Hospital, Beijing, Beijing, China, 2 Department of Stomatology, PLA General Hospital, Beijing, China, 3 Department of Biomedical Engineering, Peking University, Beijing, China, 4 Department of Radiology, PLA General Hospital, Beijing, China

The current study for the first time demonstrated the disrupted topological organization in c-ASD specific to school age children using DTI. MRI scanning was performed on 21 children with c-ASD and 21 age and gender matched healthy controls. Compared with HC, decreased characteristic path length (Lp), increased global efficiency and clustering coefficient were observed in c-ASD group, while no group effects were found in other global topological patterns. Our results suggested that both the global and regional topological patterns were disrupted in c-ASD, which might provide key neuroimaging biomarkers to classify the patients with c-ASD.

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