Meeting Banner
Abstract #3435

Impaired white matter cerebrovascular reactivity in sickle cell disease is associated with decreased white matter structural integrity

Paula L Croal 1 , Junseok Kim 1 , Jackie Leung 1 , and Andrea Kassner 1,2

1 Physiology & Experimental Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Both cerebrovascular reactivity impairment and white matter damage are observed in sickle cell disease, however the underlying vascular contributions are not understood. We observe a positive association in children with sickle cell disease between blood oxygenation level dependent (BOLD) cerebrovascular reactivity and fractional anisotropy (r2 = 0.997, p = 0.02) in the white matter of the right frontal cortex. These results may be interpreted such that impaired cerebrovascular reactivity leads to low-grade ischemic damage and resulting WM structural degradation in sickle cell disease. However, further investigation into this causal relationship is required via longitudinal studies.

This abstract and the presentation materials are available to members only; a login is required.

Join Here