Abstract #3436
Differential involvement of long versus short range WM connections in CVI
Corinna M Bauer 1,2 , Bang-Bon Koo 3 , Lauren Zajac 3 , and Lotfi B Merabet 1,2
1
Massachusetts Eye and Ear Infirmary, Boston,
MA, United States,
2
Harvard
Medical School, Boston, MA, United States,
3
Boston
University School of Medicine, MA, United States
Cortical/cerebral visual impairment (CVI) is the leading
cause of pediatric visual impairment in developed
countries. Despite its prevalence and breadth of
impairments, very little is known about how the
underlying structural and functional changes in the
brain relate to the observed clinical deficits
associated with CVI. This study utilizes HARDI
tractography to characterize the structural connectivity
deficits observed in CVI related to their specific
visual deficits. NBS identified networks showing
significantly decreased fiber number and step length in
CVI. Our results indicate that long range pathways
associated with the dorsal and ventral streams are
particularly affected in CVI
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