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Abstract #3436

Differential involvement of long versus short range WM connections in CVI

Corinna M Bauer 1,2 , Bang-Bon Koo 3 , Lauren Zajac 3 , and Lotfi B Merabet 1,2

1 Massachusetts Eye and Ear Infirmary, Boston, MA, United States, 2 Harvard Medical School, Boston, MA, United States, 3 Boston University School of Medicine, MA, United States

Cortical/cerebral visual impairment (CVI) is the leading cause of pediatric visual impairment in developed countries. Despite its prevalence and breadth of impairments, very little is known about how the underlying structural and functional changes in the brain relate to the observed clinical deficits associated with CVI. This study utilizes HARDI tractography to characterize the structural connectivity deficits observed in CVI related to their specific visual deficits. NBS identified networks showing significantly decreased fiber number and step length in CVI. Our results indicate that long range pathways associated with the dorsal and ventral streams are particularly affected in CVI

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