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Abstract #3437

Different genetic mutations are associated with different abnormal patterns of language white matter pathways in young children with global developmental delay

JEONG-WON JEONG 1 , Senthil Sundaram 1 , Diane C. Chugani 1 , and Harry T. Chugani 1

1 Pediatrics and Neurology, Wayne State University, Detroit, Michigan, United States

Global developmental delay (GD) refers to an etiologically heterogeneous set of neurodevelopmental disorders mediated in part by multiple genetic mutations. The present study investigates whether a "maximum a posteriori probability (MAP)" classifier, a diffusion weighted imaging (DWI) tractography method, can be used to detect unique patterns in axonal language pathways, which may be correlated to different types of genetic mutations observed in children with GD.

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