Abstract #3438
Objective Differentiation of Pure Speech Delay from Global Developmental Delay in Young Children: DWI Tractography-Based Connectome Study
JEONG-WON JEONG 1,2 , Senthil Sundaram 1,2 , Diane C. Chugani 1,2 , and Harry T. Chugani 1,2
1
Pediatrics and Neurology, Wayne State
University, Detroit, Michigan, United States,
2
Translational
Imaging Laboratory, Children's Hospital of Michigan,
Detroit, Michigan, United States
Pure speech delay (SD) is a common developmental
disorder which, according to some estimates, affects 5-8
% of the population. Speech delay may be not only an
isolated condition but can be part of a broader
condition such as global developmental delay (GD). The
present study investigates whether DWI-tractography
based-connectome can be a new imaging tool to
differentiate GD from SD in young children. The present
study found that the nodal strengths of
cognitive/language networks are reduced differently in
children with SD and GD. These different alterations may
be effective biomarkers underlying the neurocognitive
and behavioral consequences commonly identified in these
patients.
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