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Abstract #3438

Objective Differentiation of Pure Speech Delay from Global Developmental Delay in Young Children: DWI Tractography-Based Connectome Study

JEONG-WON JEONG 1,2 , Senthil Sundaram 1,2 , Diane C. Chugani 1,2 , and Harry T. Chugani 1,2

1 Pediatrics and Neurology, Wayne State University, Detroit, Michigan, United States, 2 Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, Michigan, United States

Pure speech delay (SD) is a common developmental disorder which, according to some estimates, affects 5-8 % of the population. Speech delay may be not only an isolated condition but can be part of a broader condition such as global developmental delay (GD). The present study investigates whether DWI-tractography based-connectome can be a new imaging tool to differentiate GD from SD in young children. The present study found that the nodal strengths of cognitive/language networks are reduced differently in children with SD and GD. These different alterations may be effective biomarkers underlying the neurocognitive and behavioral consequences commonly identified in these patients.

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