Abstract #3439
Brain Connectivity Increases Concurrent with Functional Improvement: Evidence from Connectome MRI in Children with Cerebral Palsy during Therapy
Zoe Englander 1,2 , Jessica Sun 3,4 , Laura Case 5 , Mohamad Mikati 3 , Joanne Kurtzberg 3,4 , and Allen W Song 1,6
1
Brain Imaging and Analysis Center, Duke
University, Durham, North Carolina, United States,
2
Department
of Biomedical Engineering, Duke University, Durham,
North Carolina, United States,
3
Department
of Pediatrics, Duke University, Durham, North Carolina,
United States,
4
The
Robertson Cell and Translational Therapy Center, Duke
University, Durham, North Carolina, United States,
5
Department
of Physical Therapy, Duke University, Durham, North
Carolina, United States,
6
Department
of Radiology, Duke University, Durham, North Carolina,
United States
Brain connectivity changes, measured using diffusion
tensor imaging (DTI), were examined in relation to
changes in motor functional ability in young children
with cerebral palsy (CP) undergoing therapy. Strong
correlations between changes in connectivity and changes
in motor function were identified. Children with greater
connectivity at time of enrollment tended to have better
functional outcomes. We identified that brain
connectivity could serve as a biomarker for treatment
efficacy in children with CP.
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