Abstract #3452
Inhomogeneous Magnetization Transfer: Developmental changes during childhood
Alyssa Mah 1 , R Marc Lebel 2,3 , David C Alsop 4 , Gopal Varma 4 , and Catherine Lebel 3
1
Biomedical Engineering Program, University
of Calgary, Calgary, AB, Canada,
2
General
Electric Healthcare Canada, Calgary, AB, Canada,
3
Radiology,
University of Calgary, Calgary, AB, Canada,
4
Radiology,
Beth Israel Deaconess Medical Center, Harvard Medical
School, Boston, MA, United States
Understanding healthy brain development is critical for
studying developmental disorders. Inhomogeneous
magnetization transfer (ihMT) is able to virtually
eliminate signal from unmyelinated tissues, and may
provide a biomarker specific to myelination, an
important part of brain development. We used ihMT and
MTI to characterize the white matter (WM) of healthy
children aged 2-4 and 8-13 years. While qMT was
significantly different in most WM areas between groups,
qihMT was only significantly different in the cingulum
and genu of the corpus callosum. This indicates
myelination in these frontal tracts, while changes in
qMT may indicate other maturation changes in
macromolecular content.
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