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Abstract #3452

Inhomogeneous Magnetization Transfer: Developmental changes during childhood

Alyssa Mah 1 , R Marc Lebel 2,3 , David C Alsop 4 , Gopal Varma 4 , and Catherine Lebel 3

1 Biomedical Engineering Program, University of Calgary, Calgary, AB, Canada, 2 General Electric Healthcare Canada, Calgary, AB, Canada, 3 Radiology, University of Calgary, Calgary, AB, Canada, 4 Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Understanding healthy brain development is critical for studying developmental disorders. Inhomogeneous magnetization transfer (ihMT) is able to virtually eliminate signal from unmyelinated tissues, and may provide a biomarker specific to myelination, an important part of brain development. We used ihMT and MTI to characterize the white matter (WM) of healthy children aged 2-4 and 8-13 years. While qMT was significantly different in most WM areas between groups, qihMT was only significantly different in the cingulum and genu of the corpus callosum. This indicates myelination in these frontal tracts, while changes in qMT may indicate other maturation changes in macromolecular content.

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