Investigating Cortical Myelination and Maturation using Quantitative Myelin Water Fraction and Relaxation Time Imaging
Sean Deoni 1 , Justin Remer 1 , Douglas Dean 1 , and Jonathan OMuircheartaigh 2
Advanced Baby Imaging Lab, Brown University,
Providence, RI, United States,
King's College London, London, England, United Kingdom
The development and maturation of the cortical
myeloarchitecture is an important, yet understudied,
aspect of early childhood brain development. In this
work, we sought to demonstrate the ability of
quantitative myelin water fraction and relaxation time
imaging to investigate cortical myelination and
maturation in a large cohort of healthy and
typically-developing children from 1 to 6 years of age.
We reveal cortical maturation profiles across this
age-range for the first time, and demonstrate their
consistency with prior histological data.
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