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Abstract #3453

Investigating Cortical Myelination and Maturation using Quantitative Myelin Water Fraction and Relaxation Time Imaging

Sean Deoni 1 , Justin Remer 1 , Douglas Dean 1 , and Jonathan OMuircheartaigh 2

1 Advanced Baby Imaging Lab, Brown University, Providence, RI, United States, 2 Neuroimaging, King's College London, London, England, United Kingdom

The development and maturation of the cortical myeloarchitecture is an important, yet understudied, aspect of early childhood brain development. In this work, we sought to demonstrate the ability of quantitative myelin water fraction and relaxation time imaging to investigate cortical myelination and maturation in a large cohort of healthy and typically-developing children from 1 to 6 years of age. We reveal cortical maturation profiles across this age-range for the first time, and demonstrate their consistency with prior histological data.

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