Abstract #3454
Validating a cross-sectional brain development index with longitudinal brain images
Bo Cao 1 , Benson Mwangi 1 , Khader M. Hasan 2 , Sudhakar Selvaraj 1 , Giovana B. Zunta-Soares 1 , and Jair C. Soares 1
1
Psychiatry and Behavioral Sciences,
University of Texas Health Science Center at Houston,
Houston, TX, United States,
2
Department
of Diagnostic & Interventional Imaging, University of
Texas Health Science Center at Houston, Houston, TX,
United States
The brain development index developed in this study
accurately predicted individual brain development of 303
children and adolescents for their first visit with
cross-validations. The brain development index was
further validated with 115 subjects, who were re-scanned
at the second visit after 2 years. The accuracy of this
longitudinal validation with second visit scans was
comparable to that of the cross-validation with first
visit scans. The index captured the neuroanatomical
volume changes between the two visits. The brain
development index can be applied to detect individuals
following an atypical neurodevelopment and at risk of
developing severe psychopathology.
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