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Abstract #3455

Examining the Relationships between Cortical Maturation and White Matter Myelination throughout Early Childhood

Elise Croteau-Chonka 1 , Justin Remer 2 , Jonathan O'Muircheartaigh 3 , Holly Dirks 2 , Doug Dean III 4 , and Sean Deoni 2

1 Advanced Baby Imaging Lab, Brown University, Providence, Rhode Island, United States, 2 Advanced Baby Imaging Lab, Brown University, Rhode Island, United States, 3 King's College London, England, United Kingdom, 4 Waisman Center, University of Wisconsin-Madison, Wisconsin, United States

Two important neurodevelopmental processes that occur throughout infancy and early childhood are the maturation of the myelinated white matter and cortical development (including changes in thickness, surface area, gyrification, and volume). Few prior studies have investigated the relationship between these two processes. Here, we investigate these related processes for the first time in a large cohort of young children 1-6 years of age. We show that, while related, cortical thickness and adjacent white matter maturation are not proxies for one another in this age group.

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