Abstract #3456
Age-related R2* Values Variation in Gray Matter from Birth to 5 Years Detected by Using an Atlas-based Analysis
Ning Ning 1,2 , Yajie Hu 1,3 , Xianjun Li 1,3 , Qinli Sun 1 , Yanyan Li 1 , and Jian Yang 1,3
1
Department of Radiology, The First
Affiliated Hospital of Medical College, Xi'an Jiaotong
University, Xi'an, Shaanxi, China,
2
Department
of Nuclear medicine, The Second Affiliated Hospital of
Medical College, Xi'an Jiaotong University, Xi'an,
Shaanxi, China,
3
Department
of Biomedical Engineering, School of Life Science and
Technology, Xi'an Jiaotong University, Xi'an, Shaanxi,
China
It aims to extract the R2* values by using an
atlas-based analysis, and to evaluate the age-related
R2* changes and the potentiality for monitoring iron
deposition in the gray matter of the infants and
preschool children. 83 subjects (age: 3 days-51 months)
were examined by using an enhanced T2* weighted
angiography sequence. A coregistration of R2* to high
resolution 3D-T1 anatomical images was performed, and
the R2* values were extracted automatically in the
cerebral cortex and deep gray nuclei. R2* values showed
a significant and positive correlation with age, as well
as the reference of iron content. It indicated the
changes of R2* values could reflect the age-related and
spatial difference of the early iron deposition in gray
matter, and this atlas-based analysis may be a feasible
method for R2* measurement in early brain development.
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