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Abstract #3457

Regional differences in CVR developmental patterns in healthy children

Jackie Leung 1 , Junseok Kim 2 , Przemyslaw Kosinski 2 , and Andrea Kassner 1,3

1 The Hospital for Sick Children, Toronto, Ontario, Canada, 2 Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, 3 Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Cerebrovascular reactivity (CVR) measures the capacity of cerebral blood vessels to dilate in response to a vasoactive stimulus. Global CVR has recently been shown to change significantly during childhood and adolescence, but very little is currently known about regional changes of CVR with age. This information can refine our understanding of cerebral physiology in children. The purpose of this study was to determine whether the developmental trajectories of CVR in children are region specific. Our findings suggest that the evolution of CVR is regionally dependent, differing in both rate of change and age of peak CVR.

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