Abstract #3458
Investigating the Age Modulation of Functional Connectivity in a Pediatric Population Using Multi-echo EPI
Binjian Sun 1 , Thomas G Burns 1 , Thaddeus Reece 1 , Laura L Hayes 1 , Kamilah Hendrix 1 , and Richard A Jones 1,2
1
Children's Healthcare of Atlanta, Atlanta,
GA, United States,
2
Emory
University, Atlanta, GA, United States
In this study, we used single shot, multi-echo fcMRI
data on 25 normal pediatric controls to investigate the
age dependence of local and remote functional
connectivity. The results show that local connectivity
exhibited an age dependent decrease in the (bilateral)
frontal and temporal lobes, whereas remote connectivity
showed age modulated increase in the frontal-parietal
network. No age dependent increases of local
connectivity or age dependent decreases of remote
connectity were identified. This result echoes the
findings of previous graph theory based analysis which
concluded that the functional networks evolve from local
connections to distributed networks as brain matures.
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