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Abstract #3458

Investigating the Age Modulation of Functional Connectivity in a Pediatric Population Using Multi-echo EPI

Binjian Sun 1 , Thomas G Burns 1 , Thaddeus Reece 1 , Laura L Hayes 1 , Kamilah Hendrix 1 , and Richard A Jones 1,2

1 Children's Healthcare of Atlanta, Atlanta, GA, United States, 2 Emory University, Atlanta, GA, United States

In this study, we used single shot, multi-echo fcMRI data on 25 normal pediatric controls to investigate the age dependence of local and remote functional connectivity. The results show that local connectivity exhibited an age dependent decrease in the (bilateral) frontal and temporal lobes, whereas remote connectivity showed age modulated increase in the frontal-parietal network. No age dependent increases of local connectivity or age dependent decreases of remote connectity were identified. This result echoes the findings of previous graph theory based analysis which concluded that the functional networks evolve from local connections to distributed networks as brain matures.

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