Abstract #3460
Optimized multi-shell HARDI acquisiton with alternating phase encoding directions for neonatal dMRI
Jana Hutter 1,2 , Jacques-Donald Tournier 1 , Emer J. Hughes 1 , Anthony N. Price 1 , Lucilio Cordero-Grande 1,2 , Rita G. Nunes 1 , Rui Pedro A. G. Teixeira 1,2 , Serena J. Counsell 1 , Jesper L. R. Andersson 3 , Daniel Rueckert 4 , A. David Edwards 1,2 , and Jo V. Hajnal 1,2
1
Centre for the Developing Brain, King's
College London, London, London, United Kingdom,
2
Division
of Imaging Sciences and Biomedical Engineering, King's
College London, London, London, United Kingdom,
3
FMRIB,
Oxford, Oxfordshire, United Kingdom,
4
Biomedical
Image Analysis Group, Department of Computing, Imperial
College London, London, United Kingdom
The developing human connectome project (dHCP) aspires
to get multi-shell diffusion data with comparable
resolution, high SNR and high spherical coverage than
the human connectome project in 1000 infants in natural
sleep. The developed sequence combines a modified pulses
gradient diffusion preparation that minimizes echo time
and an optimized interleaved distribution of
sensitization directions and phase encoding directions
in one single self-calibrating scan to optimize
efficiency and produce information rich data that is
tolerant of signal loss due to sporadic movements, which
is a common pattern in neonates.
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