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Abstract #3460

Optimized multi-shell HARDI acquisiton with alternating phase encoding directions for neonatal dMRI

Jana Hutter 1,2 , Jacques-Donald Tournier 1 , Emer J. Hughes 1 , Anthony N. Price 1 , Lucilio Cordero-Grande 1,2 , Rita G. Nunes 1 , Rui Pedro A. G. Teixeira 1,2 , Serena J. Counsell 1 , Jesper L. R. Andersson 3 , Daniel Rueckert 4 , A. David Edwards 1,2 , and Jo V. Hajnal 1,2

1 Centre for the Developing Brain, King's College London, London, London, United Kingdom, 2 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, London, United Kingdom, 3 FMRIB, Oxford, Oxfordshire, United Kingdom, 4 Biomedical Image Analysis Group, Department of Computing, Imperial College London, London, United Kingdom

The developing human connectome project (dHCP) aspires to get multi-shell diffusion data with comparable resolution, high SNR and high spherical coverage than the human connectome project in 1000 infants in natural sleep. The developed sequence combines a modified pulses gradient diffusion preparation that minimizes echo time and an optimized interleaved distribution of sensitization directions and phase encoding directions in one single self-calibrating scan to optimize efficiency and produce information rich data that is tolerant of signal loss due to sporadic movements, which is a common pattern in neonates.

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