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Abstract #3461

High-field neurite orientation dispersion and density imaging of sheep brain development

Yohan van de Looij 1 , Justin M Dean 2 , Alistair J Gunn 2 , Petra S Hppi 1 , and Stphane V Sizonenko 1

1 Division of Child Growth and Development, University of Geneva, Geneva, Switzerland, 2 Department of Physiology, University of Auckland, Auckland, New Zealand

Parameters derived from diffusion tensor imaging (diffusivities and fractional anisotropy) are not specific to, the tissues microstructure. Recently, the neurite orientation dispersion and density imaging (NODDI), estimating the microstructural complexity of neuritis has been developed. In this work we aimed to study ex-vivo brain development of a gyrencephalic specie (sheep brain) at different gestational ages by using DWI acquisition at 9.4T fitted with the NODDI model. NODDI modelling leads to more specific markers of the tissues microstructure development and will be of high interest to study gyrified models of perinatal brain injury as well as in clinical practice.

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