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Abstract #3462

How does white matter microstructure change in human early development based on WMTI and NODDI?

Ileana O. Jelescu 1 , Jelle Veraart 1 , Vitria Adisetiyo 1 , Sarah Milla 1 , Dmitry S. Novikov 1 , and Els Fieremans 1

1 Center for Biomedical Imaging, Dept. of Radiology, NYU Langone Medical Center, New York, New York, United States

White matter microstructural changes during the first three years of healthy brain development are characterized using two models developed for limited clinical diffusion data: White Matter Tract Integrity (WMTI) metrics and Neurite Orientation Dispersion and Density Imaging (NODDI). Both models reveal a non-linear increase in intra-axonal water fraction and in tortuosity of the extra-axonal space as a function of age, in the genu, splenium and posterior limb of the internal capsule. The changes are consistent with myelination and asynchrony of fiber development. The quantitative differences in parameter estimates between models are explained by each model's assumptions and consequent biases.

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