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Abstract #3463

NODDI intra-axonal volume fraction shows stronger correlation with developmental age than fractional anisotropy in preterm human newborns

Nicolas Kunz 1 , Juliane Schneider 2 , Lana Vasung 3 , Hui Zhang 4 , Patrick Hagmann 5 , Anita C Truttmann 2 , Franois Lazeyras 6 , and Petra Susan Hppi 3

1 CIBM-AIT, EPFL, Lausanne, Vaud, Switzerland, 2 Unit of Neonatology and Follow up, Department of Pediatrics, Centre hospitalier universitaire Vaudois (CHUV), Vaud, Switzerland, 3 Division of Development and Growth, Dept of Pediatrics, University of Geneva, Geneva, Geneva, Switzerland, 4 Computer Science, University College London, London, United Kingdom, 5 Department of Radiology, Centre hospitalier universitaire Vaudois (CHUV), Vaud, Switzerland, 6 Department of Radiology-CIBM, Geneva University Hospitals (HUG), Geneva, Switzerland

In this work, we investigate in a cohort premature neonate born before the 30th weeks of gestation over multiple time points (31st, 35th and 40th of gestational age) the changes of the intra-axonal volume fraction (ficvf) and orientation dispersion index (ODI) of the NODDI biophysical diffusion compartment model. ficvf shows stronger correlation with age than conventional FA, whereas ODI did not show any significant changes with development. It suggests an increase of the axonal space (in preparation for myelination), with a preservation of the global organization of the newborn white matter tracts.

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