Abstract #3463
NODDI intra-axonal volume fraction shows stronger correlation with developmental age than fractional anisotropy in preterm human newborns
Nicolas Kunz 1 , Juliane Schneider 2 , Lana Vasung 3 , Hui Zhang 4 , Patrick Hagmann 5 , Anita C Truttmann 2 , Franois Lazeyras 6 , and Petra Susan Hppi 3
1
CIBM-AIT, EPFL, Lausanne, Vaud, Switzerland,
2
Unit
of Neonatology and Follow up, Department of Pediatrics,
Centre hospitalier universitaire Vaudois (CHUV), Vaud,
Switzerland,
3
Division
of Development and Growth, Dept of Pediatrics,
University of Geneva, Geneva, Geneva, Switzerland,
4
Computer
Science, University College London, London, United
Kingdom,
5
Department
of Radiology, Centre hospitalier universitaire Vaudois
(CHUV), Vaud, Switzerland,
6
Department of
Radiology-CIBM, Geneva University Hospitals (HUG),
Geneva, Switzerland
In this work, we investigate in a cohort premature
neonate born before the 30th weeks of gestation over
multiple time points (31st, 35th and 40th of gestational
age) the changes of the intra-axonal volume fraction
(ficvf) and orientation dispersion index (ODI) of the
NODDI biophysical diffusion compartment model. ficvf
shows stronger correlation with age than conventional
FA, whereas ODI did not show any significant changes
with development. It suggests an increase of the axonal
space (in preparation for myelination), with a
preservation of the global organization of the newborn
white matter tracts.
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