Meeting Banner
Abstract #3464

White matter changes of neurite density and fiber orientation dispersion during human brain maturation

Yi-Shin Chang 1 , Julia P Owen 1 , Nicholas J Pojman 1 , Tony Thieu 1 , Polina Bukshpun 1 , Mari Wakahiro 1 , Jeffrey Berman 2 , Timothy Roberts 2 , Srikantan Nagarajan 1 , Elliott Sherr 1 , and Pratik Mukherjee 1

1 University of California in San Francisco, San Francisco, California, United States, 2 Children's Hospital of Philadelphia, Pennsylvania, United States

In this study, we apply NODDI in healthy controls ages 7-63 to investigate changes of fiber orientation index (ODI) and neurite density index (NDI) with brain maturation, with comparison to standard DTI metrics. Our results reveal that, while NDI increases rapidly in childhood and more slowly in adulthood, ODI increases more slowly in childhood, and accelerates in adulthood. These results suggest that the rise of FA during the first two decades of life is dominated by increasing NDI, while the fall in FA during late adulthood is driven by the exponential rise of ODI that overcomes slower increases of NDI.

This abstract and the presentation materials are available to members only; a login is required.

Join Here