Abstract #3466
Combination of high resolution ex vivo diffusion tensor imaging and tract-based spatial statistics serve as a valuable user-independent method to evaluate long-term effects of an inflammatory exposure in the neonatal rat brain
Chen Jin 1 , Alexandre Castonguay 2 , Julie Tremblay 1 , Philippe Pouliot 2,3 , Irene Londono 1 , Frdric Lesage 2,3 , and Gregory A. Lodygensky 1,3
1
Research Centre CHU Sainte-Justine,
Montreal, Quebec, Canada,
2
cole
Polytechnique de Montral, Montreal, Quebec, Canada,
3
Montreal
Heart Institute, Montreal, Quebec, Canada
High resolution DTI combined with TBSS allows for a
systematic and automated approach to assess inflammatory
white matter injury in a neonatal rat model. Animals
received either intracerebral LPS or saline injections
at 3 days of age. Ex vivo DTI was performed on whole
extracted brains at 24 days of age, followed by TBSS on
FA maps. We found an increased fractional anisotropy in
the contralateral external capsule, which possibly
reflects an increased plasticity following neonatal
white matter injury. Understanding underlying changes
behind FA increase is underway using depth-resolved
optical coherence tomography imaging.
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