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Abstract #3466

Combination of high resolution ex vivo diffusion tensor imaging and tract-based spatial statistics serve as a valuable user-independent method to evaluate long-term effects of an inflammatory exposure in the neonatal rat brain

Chen Jin 1 , Alexandre Castonguay 2 , Julie Tremblay 1 , Philippe Pouliot 2,3 , Irene Londono 1 , Frdric Lesage 2,3 , and Gregory A. Lodygensky 1,3

1 Research Centre CHU Sainte-Justine, Montreal, Quebec, Canada, 2 cole Polytechnique de Montral, Montreal, Quebec, Canada, 3 Montreal Heart Institute, Montreal, Quebec, Canada

High resolution DTI combined with TBSS allows for a systematic and automated approach to assess inflammatory white matter injury in a neonatal rat model. Animals received either intracerebral LPS or saline injections at 3 days of age. Ex vivo DTI was performed on whole extracted brains at 24 days of age, followed by TBSS on FA maps. We found an increased fractional anisotropy in the contralateral external capsule, which possibly reflects an increased plasticity following neonatal white matter injury. Understanding underlying changes behind FA increase is underway using depth-resolved optical coherence tomography imaging.

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