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Abstract #3469

Exploring the early organization and maturation of linguistic pathways in the human infant brain

Jessica Dubois 1,2 , Cyril Poupon 3 , Bertrand Thirion 2,4 , Sofya Kulikova 5 , Franois Leroy 1,2 , Lucie Hertz-Pannier 5 , and Ghislaine Dehaene-Lambertz 1,2

1 Cognitive Neuroimaging Unit, INSERM, Gif-sur-Yvette, France, 2 NeuroSpin, CEA, Gif-sur-Yvette, France, 3 NeuroSpin, UNIRS, CEA, Gif-sur-Yvette, France, 4 Parietal, INRIA, Gif-sur-Yvette, France, 5 NeuroSpin, UNIACT, U1129, INSERM-CEA, Gif-sur-Yvette, France

To understand how perisylvian regions collaborate from the preterm period on, we investigated the development of the language network bundles during the first stages of language acquisition. Using diffusion imaging, tractography and DTI parameters in 6- to 22w-old infants, we demonstrated structural similarities between infants and adults in the organization and microstructure of white matter bundles, especially with a segregation between dorsal and ventral pathways. According to normalized transverse diffusivity, we further highlighted the developmental calendar of these bundles: the ventral pathway starts maturing before the dorsal pathway, nevertheless the dorsal maturation catches up during the first post-natal months.

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