Abstract #3470
The role of glial fibers in human fetal connectome with high resolution diffusion tensor imaging
Virendra Mishra 1 , Tina Jeon 2 , Mihovil Pletikos 3 , Nenad Sestan 3 , and Hao Huang 1
1
Advanced Imaging Research Center, University
of Texas Southwestern Medical Center, Dallas, Texas,
United States,
2
Advanced
Imaging Research Center, University of Texas
Southwestern Medical Center, Texas, United States,
3
Department
of Neurobiology, Yale University, CT, United States
The formation of human brain connectome in the fetal
stage is poorly understood. Both fetal axons and
transient glial fibers exist in the fetal brain. In this
study, we aimed to explore the role of the glial fibers
in constructing human brain connectome in the fetal
stage. High resolution DTI data was acquired from ex
vivo fetal brains at 13 weeks of gestation (wg), 15wg,
17wg and 19wg. Based on DTI tractography and cortical
parcellation, brain network properties based on graph
theory were measured with the connectivity contributed
by glial fibers only, axons only and both glial fibers
and axons.
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