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Abstract #3470

The role of glial fibers in human fetal connectome with high resolution diffusion tensor imaging

Virendra Mishra 1 , Tina Jeon 2 , Mihovil Pletikos 3 , Nenad Sestan 3 , and Hao Huang 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Texas, United States, 3 Department of Neurobiology, Yale University, CT, United States

The formation of human brain connectome in the fetal stage is poorly understood. Both fetal axons and transient glial fibers exist in the fetal brain. In this study, we aimed to explore the role of the glial fibers in constructing human brain connectome in the fetal stage. High resolution DTI data was acquired from ex vivo fetal brains at 13 weeks of gestation (wg), 15wg, 17wg and 19wg. Based on DTI tractography and cortical parcellation, brain network properties based on graph theory were measured with the connectivity contributed by glial fibers only, axons only and both glial fibers and axons.

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