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Abstract #3471

Sex differences in the frontal lobe of the developing mouse brain

Da Shi 1,2 , Jiachen Zhuo 1,2 , Su Xu 1,2 , Jaylyn Waddell 3 , and Rao P Gullapalli 1,2

1 Core for Translational Research in Imaging at University of Maryland, University of Maryland School of Medicine, Baltimore, MD, United States, 2 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 3 Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States

The frontal lobe is an integral competent of the limbic system that governs emotion, motivation, reward and memory. The development of the frontal lobe showed different trajectories between males and females, consistent with findings of differences in overall brain volume between male and female. This study measured structural connectivity, an indication of physical connections within and between brain regions, in the developing frontal lobe of male and female mice. Differences in structural connectivity were revealed mainly in cortical regions during periods of synapse overproduction and pruning in male and female mice, but not between white matter to cortical regions.

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