Sex differences in the frontal lobe of the developing mouse brain
Da Shi 1,2 , Jiachen Zhuo 1,2 , Su Xu 1,2 , Jaylyn Waddell 3 , and Rao P Gullapalli 1,2
Core for Translational Research in Imaging
at University of Maryland, University of Maryland School
of Medicine, Baltimore, MD, United States,
of Diagnostic Radiology and Nuclear Medicine, University
of Maryland School of Medicine, Baltimore, MD, United
of Pediatrics, University of Maryland School of
Medicine, Baltimore, MD, United States
The frontal lobe is an integral competent of the limbic
system that governs emotion, motivation, reward and
memory. The development of the frontal lobe showed
different trajectories between males and females,
consistent with findings of differences in overall brain
volume between male and female. This study measured
structural connectivity, an indication of physical
connections within and between brain regions, in the
developing frontal lobe of male and female mice.
Differences in structural connectivity were revealed
mainly in cortical regions during periods of synapse
overproduction and pruning in male and female mice, but
not between white matter to cortical regions.
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