Meeting Banner
Abstract #3472

The detection of microstructural changes in cerebral gray matter nuclei between healthy neonates and young adults by diffusional kurtosis imaging

Qinli Sun 1 , Xianjun Li 1,2 , Yanyan Li 1 , Jie Gao 1 , Huan Li 1 , and Jian Yang 1,2

1 Department of Diagnostic Radiology, The First Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi, China, 2 Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, China

In this study, we compare the sensitivity between diffusion tensor and kurtosis metrics on detecting the changes of the cerebral gray matter nuclei between health neonates and young adults. Twenty-two term neonates and twenty-two young adults underwent diffusional kurtosis imaging. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD), Mean kurtosis (MK), axial kurtosis (AK) and radial kurtosis (RK) were calculated in four cerebral gray matter nuclei including thalamus, putamen, globus pallidus and caudate nucleus. There were significant differences for all seven parameters between neonates and adults in four GM regions (p<0.05), except AD in thalamus(p=0.944). The relative change of the kurtosis metrics varied from 82.86% to 210.81% while that of diffusion tensor metrics just from 1.45% to 70.59%. The kurtosis metrics had bigger variations than those in the diffusion tensor metrics. DKI offers a more comprehensive and sensitive characters for detection of microstructural changes by measuring directionally specific diffusivity and kurtosis, and has the potential to explore the development process of gray matter.

This abstract and the presentation materials are available to members only; a login is required.

Join Here