Abstract #3472
The detection of microstructural changes in cerebral gray matter nuclei between healthy neonates and young adults by diffusional kurtosis imaging
Qinli Sun 1 , Xianjun Li 1,2 , Yanyan Li 1 , Jie Gao 1 , Huan Li 1 , and Jian Yang 1,2
1
Department of Diagnostic Radiology, The
First Hospital of Medical School, Xi'an Jiaotong
University, Xi'an, Shaanxi, China,
2
Department
of Biomedical Engineering, School of Life Science and
Technology, Xi'an Jiaotong University, Xi'an, Shaanxi,
China
In this study, we compare the sensitivity between
diffusion tensor and kurtosis metrics on detecting the
changes of the cerebral gray matter nuclei between
health neonates and young adults. Twenty-two term
neonates and twenty-two young adults underwent
diffusional kurtosis imaging. Fractional anisotropy
(FA), mean diffusivity (MD), radial diffusivity (RD),
axial diffusivity (AD), Mean kurtosis (MK), axial
kurtosis (AK) and radial kurtosis (RK) were calculated
in four cerebral gray matter nuclei including thalamus,
putamen, globus pallidus and caudate nucleus. There were
significant differences for all seven parameters between
neonates and adults in four GM regions (p<0.05), except
AD in thalamus(p=0.944). The relative change of the
kurtosis metrics varied from 82.86% to 210.81% while
that of diffusion tensor metrics just from 1.45% to
70.59%. The kurtosis metrics had bigger variations than
those in the diffusion tensor metrics. DKI offers a more
comprehensive and sensitive characters for detection of
microstructural changes by measuring directionally
specific diffusivity and kurtosis, and has the potential
to explore the development process of gray matter.
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