Meeting Banner
Abstract #3513

In vivo structural template of human brainstem nuclei based on multi-contrast MRI at 7 Tesla

Marta Bianciardi 1 , Nicola Toschi 1,2 , Brian L. Edlow 3 , Cornelius Eichner 1 , Kawin Setsompop 1 , Jonathan R Polimeni 1 , Emery N Brown 4 , Hannah C Kinney 5 , Bruce R Rosen 1 , and Lawrence L Wald 1

1 Department of Radiology, A.A. Martinos Center for Biomedical Imaging, MGH and Harvard Medical School, Boston, MA, United States, 2 Medical Physics Section, Department of Biomedicine and Prevention, Faculty of Medicine, University of Rome Tor Vergata, Rome, Italy, 3 Department of Neurology, A. A. Martinos Center for Biomedical Imaging, MGH & Harvard Medical School, Boston, MA, United States, 4 Department of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, United States, 5 Department of Pathology, Boston Childrens Hospital, Harvard Medical School, Boston, MA, United States

Despite spectacular advances in neuroimaging of the human cerebral gray-matter, in-vivo visualization of human brainstem nuclei (Bn) is more challenging because of the limited sensitivity and contrast between Bn and adjacent white-matter using standard neuroimaging methods. Through combined examination of 1.1mm-isotropic multi-contrast (diffusion-fractional-anisotropy and T2-weighted) anatomical images acquired at 7 Tesla, we automatically generated in-vivo probabilistic brainstem labels of subcortical hubs of the ascending-arousal, autonomic and motor systems. These labels constitute a first step in the development of an in-vivo neuroimaging template of Bn in standard space to facilitate future clinical and research investigations of human brainstem function and pathology.

This abstract and the presentation materials are available to members only; a login is required.

Join Here