Abstract #3513
In vivo structural template of human brainstem nuclei based on multi-contrast MRI at 7 Tesla
Marta Bianciardi 1 , Nicola Toschi 1,2 , Brian L. Edlow 3 , Cornelius Eichner 1 , Kawin Setsompop 1 , Jonathan R Polimeni 1 , Emery N Brown 4 , Hannah C Kinney 5 , Bruce R Rosen 1 , and Lawrence L Wald 1
1
Department of Radiology, A.A. Martinos
Center for Biomedical Imaging, MGH and Harvard Medical
School, Boston, MA, United States,
2
Medical
Physics Section, Department of Biomedicine and
Prevention, Faculty of Medicine, University of Rome Tor
Vergata, Rome, Italy,
3
Department
of Neurology, A. A. Martinos Center for Biomedical
Imaging, MGH & Harvard Medical School, Boston, MA,
United States,
4
Department
of Anesthesia, Critical Care and Pain Medicine, MGH,
Boston, MA, United States,
5
Department
of Pathology, Boston Childrens Hospital, Harvard
Medical School, Boston, MA, United States
Despite spectacular advances in neuroimaging of the
human cerebral gray-matter, in-vivo visualization of
human brainstem nuclei (Bn) is more challenging because
of the limited sensitivity and contrast between Bn and
adjacent white-matter using standard neuroimaging
methods. Through combined examination of 1.1mm-isotropic
multi-contrast (diffusion-fractional-anisotropy and
T2-weighted) anatomical images acquired at 7 Tesla, we
automatically generated in-vivo probabilistic brainstem
labels of subcortical hubs of the ascending-arousal,
autonomic and motor systems. These labels constitute a
first step in the development of an in-vivo neuroimaging
template of Bn in standard space to facilitate future
clinical and research investigations of human brainstem
function and pathology.
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