Abstract #3514
Structural connectivity mapping and parcellation of the human subthalamic nucleus using ultra-high field diffusion MRI
Birgit Renske Plantinga 1,2 , Alard Roebroeck 3 , Matteo Bastiani 3 , Valentin Gereon Kemper 3 , Maartje Melse 1 , Kmil Uludag 3 , Mark Kuijf 4 , Ali Jahanshahi 1 , Bart ter Haar Romenij 2 , and Yasin Temel 1,5
1
Department of Neuroscience, Maastricht
University, Maastricht, Limburg, Netherlands,
2
Biomedical
Image Analysis, Eindhoven University of Technology,
Eindhoven, Noord-Brabant, Netherlands,
3
Department
of Cognitive Neuroscience, Maastricht University,
Maastricht, Limburg, Netherlands,
4
Department
of Neurology, Maastricht University Medical Center,
Maastricht, Limburg, Netherlands,
5
Department
of Neurosurgery, Maastricht University Medical Center,
Maastricht, Limburg, Netherlands
Ultra-high field diffusion weighted ex vivo MRI was used
to investigate the connectivity profile and parcellation
of the human subthalamic nucleus (STN) at high
resolution. The results show a more pronounced
connection to the substantia nigra pars compacta than
what is currently assumed. Furthermore, STN connections
to the ascending internal capsule and the anterior part
of the internal globus pallidus suggest that the
posterior dorsal part of the STN is involved in motor
and the anteromedial part is involved in limbic
processes respectively. These findings may aid in
improving the targeting in deep brain stimulation
surgery of the STN.
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