The Lower White Matter Integrity was Related to Relapse Propensity in Heroin Addicts Under Methadone Maintenance Treatment

DTI was used to assess whether white matter integrity measured at the baseline differ between patients who subsequent abstinence and those who resumed to heroin use. The results shown that future relapsers had lower white matter integrity compared with subsequent abstinence, and the white matter integrity in left posterior limb of the internal capsule correlated negatively with the heroin positive urinalysis rate. Thus the white matter integrity might be of prognostic value and added to the neurobiological relapse risk profile of heroin abuse. This findings may suggest that strategies for improving white matter integrity may developing a new interventions for the reduction of relapse in heroin addiction.

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