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Abstract #3525

Altered corticostriatal functional networks in adolescents with Internet addiction disorder revealed by resting-state fMRI

Fuchun Lin 1 , Yasong Du 2 , Yan Zhou 3 , Jianrong Xu 3 , and Hao Lei 1

1 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China, 2 Shanghai Mental Health Center, Jiao Tong University Medical School, Shanghai, China, 3 RenJi Hospital, Jiao Tong University Medical School, Shanghai, China

Resting-state functional connectivity (rsFC) was used to investigate six bilateral striatal functional networks in adolescent students with Internet addiction disorder (IAD). These functional networks involve multiple cortical and subcortical regions that are known to engage in affective and motivation processing, and cognitive control. Although both the IAD subjects and controls show similar FC patterns for six bilateral striatal subregions, however, IAD had altered connectivity strength for every striatal subregion. Moreover, the strengthes of rsFC between rVSs and dorsal ACC, between lDC and dorsal/rostral ACC, between lVRP and right IFG, were negatively correlated with SCARED, and the strength of rsFC between rVSs and dorsal caudate was negatively correlated with YIAS. Our findings suggest that IAD is associated with alterations of corticostriatal functional circuits and rsFC may be used as a qualified biomarker to understand the underlying neural mechanisms or to evaluate the effectiveness of specific early interventions in IAD.

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