Abstract #3525
Altered corticostriatal functional networks in adolescents with Internet addiction disorder revealed by resting-state fMRI
Fuchun Lin 1 , Yasong Du 2 , Yan Zhou 3 , Jianrong Xu 3 , and Hao Lei 1
1
State Key Laboratory of Magnetic Resonance
and Atomic and Molecular Physics, Wuhan Institute of
Physics and Mathematics, Chinese Academy of Sciences,
Wuhan, Hubei, China,
2
Shanghai
Mental Health Center, Jiao Tong University Medical
School, Shanghai, China,
3
RenJi
Hospital, Jiao Tong University Medical School, Shanghai,
China
Resting-state functional connectivity (rsFC) was used to
investigate six bilateral striatal functional networks
in adolescent students with Internet addiction disorder
(IAD). These functional networks involve multiple
cortical and subcortical regions that are known to
engage in affective and motivation processing, and
cognitive control. Although both the IAD subjects and
controls show similar FC patterns for six bilateral
striatal subregions, however, IAD had altered
connectivity strength for every striatal subregion.
Moreover, the strengthes of rsFC between rVSs and dorsal
ACC, between lDC and dorsal/rostral ACC, between lVRP
and right IFG, were negatively correlated with SCARED,
and the strength of rsFC between rVSs and dorsal caudate
was negatively correlated with YIAS. Our findings
suggest that IAD is associated with alterations of
corticostriatal functional circuits and rsFC may be used
as a qualified biomarker to understand the underlying
neural mechanisms or to evaluate the effectiveness of
specific early interventions in IAD.
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