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Abstract #3524

Brain Metabolite Abnormalities in Alcohol Dependent Patients Using Proton MR Spectroscopy at 3T

Hyeon-Man Baek 1,2 , Siekyeong Kim 3 , Jeonghwan Lee 3 , Youngjae Jeon 1 , Jooyun Kim 1 , and Mirim Bang 1

1 Center for MR Research, Korea Basic Science Institute, Ochang, Chungbuk, Korea, 2 University of Science & Technology, Daejeon, Korea, 3 Department of Psychiatry, Chungbuk National University, Cheongju, Chungbuk, Korea

In this study, we performed in vivo short-echo time (TE) 1H-MRS to investigate brain metabolite levels in the left DLPFC of alcohol-dependent patients and healthy controls. For quantitative spectral analysis, metabolite basis sets were acquired in-house on the same 3T MRI scanner. Significantly decreased tCho and Ins concentrations were found in the DLPFC of the alcoholics as compared to the controls (p=0.001, p=0.008, in Figure 2). In addition, there was a trend towards increasing Gln in alcoholic dependents (p=0.059). These metabolic abnormalities may be neurochemical correlate of an increased risk to develop alcoholism.

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