Abstract #3524
Brain Metabolite Abnormalities in Alcohol Dependent Patients Using Proton MR Spectroscopy at 3T
Hyeon-Man Baek 1,2 , Siekyeong Kim 3 , Jeonghwan Lee 3 , Youngjae Jeon 1 , Jooyun Kim 1 , and Mirim Bang 1
1
Center for MR Research, Korea Basic Science
Institute, Ochang, Chungbuk, Korea,
2
University
of Science & Technology, Daejeon, Korea,
3
Department
of Psychiatry, Chungbuk National University, Cheongju,
Chungbuk, Korea
In this study, we performed in vivo short-echo time (TE)
1H-MRS to investigate brain metabolite levels in the
left DLPFC of alcohol-dependent patients and healthy
controls. For quantitative spectral analysis, metabolite
basis sets were acquired in-house on the same 3T MRI
scanner. Significantly decreased tCho and Ins
concentrations were found in the DLPFC of the alcoholics
as compared to the controls (p=0.001, p=0.008, in Figure
2). In addition, there was a trend towards increasing
Gln in alcoholic dependents (p=0.059). These metabolic
abnormalities may be neurochemical correlate of an
increased risk to develop alcoholism.
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