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Abstract #3528

Prefrontal and frontal functional connectivity increases in current smokers versus non-smokers

Prantik Kundu 1 and Valerie Voon 2

1 Depts. of Radiology and Psychiatry, Icahn School of Medicine at Mt. Sinai, New York, NY, United States, 2 Department of Psychiatry, University of Cambridge, Cambridgeshire, United Kingdom

Study of functional connectivity differences between current smokers and non-smokers demonstrates highly significant increases in cortico-cortical and cortical-subocritcal connectivity of prefrontal and frontal areas associated with nicotine-stimulated cholinergic pathways. Importantly, connectivity differences were elucidated based on multi-echo fMRI, for which seed-based functional connectivity is robust to motion artifact and associated type I errors in group comparisons.

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