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Abstract #3529

Widespread White Matter Integrity Abnormalities in Cocaine Use Disorder Assessed by High Resolution dMRI and Tractography

Rafael O'Halloran 1 , Nelly Alia-Klein 2 , and Rita Z Goldstein 2

1 Radiology, Icahn School of Medicine at Mt Sinai, New York, NY, United States, 2 Psychiatry, Icahn School of Medicine at Mt Sinai, NY, United States

Previously reported white matter changes associated with cocaine use disorder (CUD) have been limited to focal areas of fractional anisotropy (FA) reduction in several areas including the corpus callosum, internal capsule, and cingulum. In this study, group FA and connectivity differences were assessed using a state-of-the-art dMRI protocol. Results indicate a more widespread reduction of FA in subjects with cocaine use disorder compared to age-matched controls, corroborating previous findings but also expanding the territory of white matter integrity changes implicated in the disease. Furthermore, connectivity analysis based on tractography showed that CUD subjects had lower connectivity than controls in several networks, the most significant of which was the right side network of the hippocampus, amygdala, posterior orbito-frontal cortex, and gyrus rectus.

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