Widespread White Matter Integrity Abnormalities in Cocaine Use Disorder Assessed by High Resolution dMRI and Tractography

Previously reported white matter changes associated with cocaine use disorder (CUD) have been limited to focal areas of fractional anisotropy (FA) reduction in several areas including the corpus callosum, internal capsule, and cingulum. In this study, group FA and connectivity differences were assessed using a state-of-the-art dMRI protocol. Results indicate a more widespread reduction of FA in subjects with cocaine use disorder compared to age-matched controls, corroborating previous findings but also expanding the territory of white matter integrity changes implicated in the disease. Furthermore, connectivity analysis based on tractography showed that CUD subjects had lower connectivity than controls in several networks, the most significant of which was the right side network of the hippocampus, amygdala, posterior orbito-frontal cortex, and gyrus rectus.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.