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Abstract #3531

Cerebral Metabolite Differences and Correlations in Short-Term Binge Ethanol-Exposed Rats: A Study of Ex Vivo Proton Nuclear Magnetic Resonance Spectroscopy at 11.7-T

Do-Wan Lee 1,2 and Bo-Young Choe 1

1 Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Seoul, Korea, 2 Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea

The first goal of this study was to determine the influence of dose-dependent short-term binge ethanol (SBE) exposure on cerebral neurochemical differences and responses among controls (CNTL) and low-(SBE-1.5) and high-(SBE-2.5) dose ethanol-exposed rats. The second goal was to determine correlations between metabolite-metabolite levels (pairs-of-metabolite-levels) using individual metabolite data from hippocampal region of SBE-exposed rats. From our results and previous studies, altered various metabolite signals may indicate that SBE-exposure leads to various biological changes, such as changes in rate of GABA and glucose synthesis, impairment of an antioxidant defense system, abnormal ATP function in energy-metabolism, and dysfunctions of anaerobic respiration.

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