Abstract #3532
Distribution of temperature changes and neurovascular coupling in rat brain following 3,4-methylenedioxymethamphetamine (MDMA,ecstasy) exposure
Daniel Coman 1 , Basavaraju G Sanganahalli 1 , Lihong Jiang 1 , Fahmeed Hyder 1,2 , and Kevin Behar 3
1
Diagnostic Radiology, Yale University, New
Haven, Connecticut, United States,
2
Biomedical
Engineering, Yale University, New Haven, Connecticut,
United States,
3
Psychiatry,
Yale University, New Haven, Connecticut, United States
MDMA use results in extreme hyperthermia. Neuroimaging
of brain temperature could provide mechanistic insights
of MDMA action. We measured spatial distributions of
MDMA-induced temperature changes and dynamics in rat
cortex using BIRDS with TmDOTMA
4-
. MDMA
induced a fast and homogenous temperature rise
throughout the cortex. The correlation between the
cortical and body temperature changes suggest that the
heat produced in the body is carried by blood to the
brain and contributes partially to cortical temperature
increase. MDMA-induced changes in temperature, blood
flow, and neuronal activity suggest a lack of
neurovascular coupling in the thalamus compared to the
cortex.
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