Abstract #3533
Neurological Study of Mouse Model of Fetal Alcohol Spectrum Disorders using Advanced Imaging Techniques
Van Nguyen 1 , Suyinn Chong 2 , Karine Mardon 1 , Quang Tieng 1 , Graham Galloway 1 , and Nyoman Kurniawan 1
1
Centre for Advanced Imaging, The University
of Queensland, Brisbane, QLD, Australia,
2
Mater
Research Institute, The University of Queensland,
Brisbane, QLD, Australia
This study aims at monitoring abnormal brain development
longitudinally in the offspring under maternal alcohol
consumption using mouse models of Fetal Alcohol Spectrum
Disorders (FASD). In-vivo volumetric MRI and
Tensor-based Morphometry are used to make comparisons
between FASD and control brains at adolescence and
adulthood. Ex-vivo Computed Tomography is used to
monitor skull development. Correlations between brain
and skull abnormalities are made. This study found that
in-utero alcohol exposure at moderate dose may cause
subtle but observable brain malformations in the
offspring that can be detected at early age and persist
into adulthood.
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